TAS-114 |
| カタログ番号GC65152 |
TAS-114 は二重の dUTPase/ジヒドロピリミジン脱水素酵素 (DPD) 阻害剤であり、フルオロピリミジンの治療効果を向上させることができます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1198221-21-4
Sample solution is provided at 25 µL, 10mM.
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TAS-114 is a dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine[1].
TAS-114 (1-10 μM; 72 hours) increases the cytotoxicity of 5-Fluorouracil (5-FU) and 5-FU,2′-deoxy-5-fluorouridine (FdUrd) against various cancer cell lines in dose-dependent manner[1].
TAS-114 (37.5-1,200 mg/kg/day; orally; 1-14 days) increases the antitumor activity of 5-FU when co-administers with Capecitabine (539 mg/kg/day) in mice[1].
[1]. Yano W, et al. TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy. Mol Cancer Ther. 2018 Aug;17(8):1683-1693.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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