Taurolithocholic Acid (sodium salt) (Synonyms: NSC 681057, Sodium taurolithocholate, TLCA) |
| カタログ番号GC44996 |
強力な胆汁うっ滞剤であるタウロリトコール酸 (ナトリウム塩) は、強力な Ca2+ アゴニストです。
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Cas No.: 6042-32-6
Sample solution is provided at 25 µL, 10mM.
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Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acid . TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells. It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis. Serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans.
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