TC-G 1005 |
| カタログ番号GC50107 |
TC-G 1005 は、BA 受容体タケダ G タンパク質共役受容体 5 (TGR5) の強力で選択的な経口活性アゴニストであり、hTGR5 および mTGR5 の EC50 はそれぞれ 0.72 および 6.2 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1415407-60-1
Sample solution is provided at 25 µL, 10mM.
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Potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475 PMID:23148522
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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