TC-I 2014 |
| カタログ番号GC34833 |
TC-I 2014 (化合物 5) は、強力で経口的に活性なベンズイミダゾール含有の一過性受容体電位メラスタチン 8 (TRPM8) アンタゴニストであり、イヌ、ヒト、ラットのチャネルでそれぞれ 0.8 nM、3.0 nM、4.4 nM の IC50 値を持っています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1221349-53-6
Sample solution is provided at 25 µL, 10mM.
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TC-I 2014 (compound 5) is a potent Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1]. TRPM8[1].
[1]. Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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