TCO-PEG8-NHS ester |
| カタログ番号GC67524 |
TCO-PEG8-NHS エステルは、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーです。
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Cas No.: 2353409-95-5
Sample solution is provided at 25 µL, 10mM.
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TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.
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