TD-165 |
| カタログ番号GC62600 |
TD-165 は、PROTAC ベースのセレブロン (CRBN) デグレーダーです。 TD-165は、セレブロン（CRBN）リガンド結合基、リンカー、およびフォン・ヒッペル・ランダウ（VHL）結合基で構成されています。
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Cas No.: 2305936-56-3
Sample solution is provided at 25 µL, 10mM.
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TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].
TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1].TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].
[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654.
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