Tectol |
| カタログ番号GC61318 |
Lippia sidoides から分離された Tectol は、ヒト白血病細胞株 HL60 および CEM に対して有意な活性を示します 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 24449-39-6
Sample solution is provided at 25 µL, 10mM.
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Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].
[1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795. [2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.
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