Tedizolid Phosphate (Synonyms: TR-701 FA) |
| カタログ番号GC45006 |
リン酸テジゾリド (TR-701FA) は、グラム陽性病原体に対する活性を持つ新規オキサゾリジノンです。
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Cas No.: 856867-55-5
Sample solution is provided at 25 µL, 10mM.
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Tedizolid phosphate is a prodrug form of tedizolid, an antibiotic with activity against Gram-positive bacteria. Tedizolid phosphate is rapidly converted by non-specific phosphatases to tedizolid, which inhibits the growth of S. aureus, S. epidermidis, E. faecalis, E. faecium, S. pneumoniae, and S. pyogenes (MICs = 0.25-1 μg/ml). In vivo, tedizolid phosphate (15 mg/kg) reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by methicillin-resistant S. aureus (MRSA). It also reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection and increases survival in a rabbit model of MRSA necrotizing pneumonia.
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