TFC 007 |
| カタログ番号GC50101 |
選択的造血プロスタグランジン D シンターゼ (H-PGDS) 阻害剤である TFC-007 は、H-PGDS 酵素に対して高い阻害活性を示します (IC50 値 83 nM)。 TFC-007 は、H-PGDS 分解誘導剤 PROTAC(H-PGDS)-1 の合成に使用できます (TFC-007 は H-PGDS に結合し、ポマリドマイドはセレブロンに結合します)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 927878-49-7
Sample solution is provided at 25 µL, 10mM.
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Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
Nabe et al (2011) Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95 27 PMID:21601002
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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