TGN 020 |
| カタログ番号GC50160 |
TGN 020 は、IC50 が 3.1 μM の選択的アクアポリン 4 (AQP4) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 51987-99-6
Sample solution is provided at 25 µL, 10mM.
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Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID:18182301 |Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID:23462267 |Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID:20924629
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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