TH5427 |
| カタログ番号GC64717 |
TH5427 は、NUDT5 活性と ADP リボース代謝をさらに研究するために使用できる有望な標的阻害剤です。 TH5427 は、乳癌細胞におけるプロゲスチン依存性、PAR 由来の核 ATP 合成、およびその後のクロマチン リモデリング、遺伝子調節、増殖をブロックします。 NUDT5 は、乳癌細胞におけるホルモン依存性遺伝子調節および増殖のレオスタットとして最近同定されました。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2253744-56-6
Sample solution is provided at 25 µL, 10mM.
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TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].
[1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250.
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