THAL-SNS-032 |
| カタログ番号GC65346 |
THAL-SNS-032 は、E3 ユビキチン リガーゼ セレブロン (CRBN) に結合するサリドマイド誘導体に結合した CDK 結合 SNS-032 リガンドからなる選択的 CDK9 分解剤 PROTAC です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2139287-33-3
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
THAL-SNS-032 selectively induces degradation of CDK9[1].THAL-SNS-032 diminishes elongating polymerase II[1].THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].
[1]. Olson CM，et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *