THP-PEG6-OH |
| カタログ番号GC65842 |
THP-PEG6-OH は、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーです。 THP-PEG6-OH は、抗体薬物複合体 (ADC) の合成に使用される非切断型 3 ユニット PEG ADC リンカーでもあります。
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Cas No.: 42607-87-4
Sample solution is provided at 25 µL, 10mM.
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THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
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