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Tocainide hydrochloride

カタログ番号GC38865

トカイニド塩酸塩はナトリウムチャネル遮断薬であり、神経膜の痛みを生み出す病巣のナトリウムチャネルを遮断します。

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Tocainide hydrochloride 化学構造

Cas No.: 71395-14-7

サイズ 価格 在庫数 個数
1mg
$139.00
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Sample solution is provided at 25 µL, 10mM.

Description of Tocainide hydrochloride

Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].

Tocainide (100 mg/kg) effectively suppresses ventricular ectopic activity in unanesthetized dogs with coronary occlusion. Termination of tocainide infusion in both digitalis toxicity and coronary occlusion models results in prompt return of ventricular ectopic activity[1].

[1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23. [2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45.

Chemical Properties of Tocainide hydrochloride

Cas No. 71395-14-7 SDF
Canonical SMILES CC(N)C(NC1=C(C)C=CC=C1C)=O.[H]Cl
Formula C11H17ClN2O M.Wt 228.72
溶解度 DMSO : 125 mg/mL (546.52 mM; Need ultrasonic); H2O : 50 mg/mL (218.61 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Tocainide hydrochloride

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1 mg 5 mg 10 mg
1 mM 4.3722 mL 21.8608 mL 43.7216 mL
5 mM 0.8744 mL 4.3722 mL 8.7443 mL
10 mM 0.4372 mL 2.1861 mL 4.3722 mL
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In vivo Formulation Calculator (Clear solution) of Tocainide hydrochloride

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 19 reference(s) in Google Scholar.)

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