TP-030-2 |
| カタログ番号GC71026 |
TP-030-2 はRIPK 1阻害剤（ヒトKi=0.43 nM、マウスIC 50=100 nM）である。
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Cas No.: 2095514-84-2
Sample solution is provided at 25 µL, 10mM.
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TP-030-2 shows inhibiton in HT29 with IC50=1.3 nM[2].
References:
[1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409.
[2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-2
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