trans-Vaccenic Acid-d13 (Synonyms: C18:1(11E)-d13, C18:1 n-7-d13, trans-11-Octadecenoic Acid-d13)

trans-Vaccenic acid-d₁₃ is intended for use an internal standard for the quantification of trans-vaccenic acid by GC- or LC-MS. trans-Vaccenic acid is an ω-7 fatty acid that has been found in bovine milk fats.¹ Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome.² It decreases hepatocellular ballooning and steatosis, markers of non-alcoholic fatty liver disease (NAFLD), in the same model. Dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr^-/- mice.³

1.Santora, J.E., Palmquist, D.L., and Roehrig, K.L.Trans-vaccenic acid is desaturated to conjugated linoleic acid in miceJ. Nutr.130(2)208-215(2000) 2.Jacome-Sosa, M.M., Borthwick, F., Mangat, R., et al.Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndromeJ. Nutr. Biochem.25(7)692-701(2014) 3.Bassett, C.M., Edel, A.L., Patenaude, A.F., et al.Dietary vaccenic acid has antiatherogenic effects in LDLr-/- miceJ. Nutr.140(1)18-24(2010)