Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine |
| カタログ番号GC62545 |
Tris[[2-(tert-ブトキシカルボニル)エトキシ]メチル]メチルアミンは、抗体薬物複合体 (ADC) の合成に使用される切断可能な PEG ADC リンカーです。アミノ-トリ-(t-ブトキシカルボニルエトキシメチル)-メタンも、PROTACの合成に使用できるPEG/アルキル/エーテルベースのPROTACリンカーです。
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![Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 化学構造](/media/struct/GC6/GC62545.png "Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 化学構造")
Cas No.: 175724-30-8
Sample solution is provided at 25 µL, 10mM.
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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Kostiainen MA, et al. Optically degradable dendrons for temporary adhesion of proteins to DNA. Chemistry. 2010 Jun 18;16(23):6912-8.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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