TRV120056 |
カタログ番号GC64201 |
TRV120056 は Gq バイアス アゴニストであり、AT1R-βarr2 融合タンパク質と比較して、AT1R-Gq 融合タンパク質で 10 倍の分子効果を示します 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 40678-47-5
Sample solution is provided at 25 µL, 10mM.
TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].
[1]. Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77.
[2]. Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24.
Average Rating: 5
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