Uniconazole (Synonyms: S 3307D,XE 1019D) |
| カタログ番号GC17112 |
植物成長遅延剤であるウニコナゾールは、アブシジン酸 (ABA) 異化作用の強力な阻害剤であり、ABA 8'-ヒドロキシラーゼに対する IC50 は 68 nM です。
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Cas No.: 83657-22-1
Sample solution is provided at 25 µL, 10mM.
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Ki = 68 nM
Uniconazole is a cytochrome P450 707As inhibitor.
Plant growth retardants (PGRs) can reduce the shoot growth of plants via inhibiting gibberellin biosynthesis. The inhibitory effects of PGRs on Arabidopsis abscisic acid (ABA) 8'-hydroxylase, a major ABA catabolic enzyme, recently identified as CYP707As, have been reported.
In vitro: In an in-vitro assay with CYP707A3 microsomes expressed in insect cells, uniconazole could inhibit CYP707A3 activity more effectively than paclobutrazol or tetcyclacis, while the other tested PGRs could not significantly inhibit it. In addition, uniconazole was also found to be a strong competitive inhibitor of ABA 8'-hydroxylase [1].
In vivo: Uniconazole-treated Arabidopsis plants displayed enhanced drought tolerance. In uniconazole-treated plants, endogenous ABA levels increased 2-fold as compared with the control, and co-application of GA(4) could not suppress such effects, suggesting that these effects were not because of gibberellin deficiency. Therefore uniconazole could effectively inhibit ABA catabolism in Arabidopsis plants [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Saito, S. ,Okamoto, M.,Shinoda, S., et al. A plant growth retardant, uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis. Bioscience, Biotechnology, and Biochemistry 70(7), 1731-1739 (2006).
| Cas No. | 83657-22-1 | SDF | |
| 同義語 | S 3307D,XE 1019D | ||
| Chemical Name | βE-[(4-chlorophenyl)methylene]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol | ||
| Canonical SMILES | ClC1=CC=C(/C=C(C(O)C(C)(C)C)/N2N=CN=C2)C=C1 | ||
| Formula | C15H18ClN3O | M.Wt | 291.8 |
| 溶解度 | ≥ 11.65mg/mL in DMSO | Storage | Store at RT |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.427 mL | 17.135 mL | 34.27 mL |
| 5 mM | 0.6854 mL | 3.427 mL | 6.854 mL |
| 10 mM | 0.3427 mL | 1.7135 mL | 3.427 mL |
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- Purity: >98.50%
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