URAT1&XO inhibitor 2 |
| カタログ番号GC71288 |
URAT1&XO inhibitor 2（化合物BDEO）はキサンチンオキシダーゼとURAT 1の二重阻害剤であり、キサンチンオキシダーゼのIC 50は3.3μMである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1239488-96-0
Sample solution is provided at 25 µL, 10mM.
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URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC50 of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a Ki value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia.
References:
[1]. Hu Q, et al. (E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1. Biomed Pharmacother. 2017 Feb;86:88-94.
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