VEGFR2 Kinase Inhibitor II |
| カタログ番号GC45142 |
血管内皮細胞増殖因子受容体2（VEGFR2、KDRおよびFLK1としても知られています）は、VEGFアイソフォームA、C、およびDに応答して血管新生、血管発達、および胚性造血を調節する受容体チロシンキナーゼです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 288144-20-7
Sample solution is provided at 25 µL, 10mM.
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Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. VEGFR2 kinase inhibitor II blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110 nM and 2 µM, respectively).
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