VIP (human, porcine, rat, ovine) (trifluoroacetate salt) (Synonyms: Vasoactive Intestinal Peptide) |
| カタログ番号GC45146 |
バソアクティブ腸管ペプチド（VIP）は、神経伝達物質およびホルモンとして機能するペプチドです。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Vasoactive intestinal peptide (VIP) is a peptide that acts as a neurotransmitter and hormone.[1],[2] It is found in the brain and peripheral nervous system and binds to VPAC1 and VPAC2 receptors (Kis = 0.15-3.16 and 1.58-15.8 nM, respectively).[1] VIP is involved in vasodilation, bronchodilation, and regulating circadian rhythm.[1],[2],[3] It also has actions in the immune system where it inhibits the production of cytokines and chemokines involved in inflammation.[2]
Reference:
[1]. Harmar, A.J., Fahrenkrug, J., Gozes, I., et al. Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br. J. Pharmacol. 166(1), 4-17 (2012).
[2]. Delgado, M., and Ganea, D. Vasoactive intestinal peptide: A neuropeptide with pleiotropic immune functions. Amino Acids 45(1), 25-39 (2013).
[3]. Wu, D., Lee, D., and Sung, Y.K. Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: A review. Respir. Res. 12:45, (2011).
| Cas No. | SDF | ||
| 同義語 | Vasoactive Intestinal Peptide | ||
| Chemical Name | Vasoactive Intestinal Peptide | ||
| Canonical SMILES | NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H] | ||
| Formula | C147H238N44O42S•XCF3COOH | M.Wt | 3325.8 |
| 溶解度 | 1mg/mL in formic acid; Water: 1mg/mL | Storage | Store at -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.3007 mL | 1.5034 mL | 3.0068 mL |
| 5 mM | 0.0601 mL | 0.3007 mL | 0.6014 mL |
| 10 mM | 0.0301 mL | 0.1503 mL | 0.3007 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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