VY-3-135 |
| カタログ番号GC64681 |
VY-3-135 は、44 nM の IC50 値を持つ強力な経口活性の安定した ACSS2 阻害剤です。 VY-3-135 は、酵素の AcCoA 合成酵素ファミリーの中で ACSS2 に特異的です。 VY-3-135 は、ACSS1 または ACSS3 の酵素活性を阻害しません。 VY-3-135 は、乳がんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1824637-41-3
Sample solution is provided at 25 µL, 10mM.
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VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1].
VY-3-135 (0.1, 1 μM; for 24 hours) blocks acetate dependent labeling of palmitate by 13C2-acetate in ACSS2low A7C11 and ACSS2high Brpkp110 cells[1].
VY-3-135 (100 mg/kg/day; PO; 30 days) represses MDA-MB-468 (ACSS2high) tumor growth but is mostly ineffective at blocking WHIM12 (ACSS2low) growth[1].
[1]. Katelyn D Miller, et al. Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. Cancer Res. 2021 Mar 1;81(5):1252-1264.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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