Zunsemetinib M-atropisomer (Synonyms: Zunsemetinib M-atropisomer; (M)-ATI-450; ATI-450 M-atropisomer; ATI-450; ATI450; ATI 450; CDD-450 M-atropisomer ; CDD 450; CDD450;) |
| カタログ番号GB62211 |
ズンセメチニブのM-アトロピ異性体は、活性を持たない異性体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1640282-44-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Zunsemetinib M-atropisomer is the inactive isomer of Zunsemetinib. Zunsemetinib, also known as ATI-450 and CDD450, is the P-atropisomer and is a potent MK2 Inhibitor. ATI-450 binds with high affinity to the interface of the p38MAPK-MK2 complex and selectively inhibits p38MAPK-catalysed phosphorylation of MK2 which stabilises the inactive conformation of MK2, and subsequently reduces inflammatory cytokine levels. ATI-450 specifically blocks the downstream MK2-mediated inflammatory drive on the p38 pathway and may therefore avoid the tachyphylaxis associated with p38 inhibitors. Note CAS#1640282-42-3 is the active P-atropisomer. CAS# 1640282-44-5 is the inactive M-astropisomer.
Review for Zunsemetinib M-atropisomer
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for Zunsemetinib M-atropisomer
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *