JWH 203 N-pentanoic acid metabolite-d5

JWH 203 N-pentanoic acid metabolite-d₅ contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 203 N-pentanoic acid metabolite by GC- or LC-mass spectrometry. JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with K_i values of 8.0 and 7.0 nM at the central (CB₁) and peripheral (CB₂) receptors, respectively.¹ Similar to the related 2'-methoxy compound JWH 250 , JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole CB compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB₁ and CB₂ CB receptors (JWH 250 K_is = 11 and 33 nM, respectively).¹ JWH 203 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine. JWH 203 is a synthetic cannabinoid (CB) that displays high affinities for both the central CB₁ receptor (K_i = 8.0 nM) and the peripheral CB₂ receptor (K_i = 7.0 nM).¹. JWH 203 N-pentanoic acid metabolite is an expected metabolite of JWH 203, based on the metabolism of similar compounds.² The physiological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.

1.Huffman, J.W., Szklennik, P.V., Almond, A., et al.1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indolesBioorg. Med. Chem. Lett.15(18)4110-4113(2005) 2.Moran, C.L., Le, V.H., Chimalakonda, K.C., et al.Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urineAnal. Chem.83(11)4228-4236(2011)