1,2-Dioleoyl-sn-glycero-3-PC (Synonyms: sn3Dioleoyllecithin, 1,2Dioleoylsnglycero3Phosphocholine, 1,2DOPC, PDD 111) |
| Catalog No.GC41814 |
1,2-Dioleoyl-sn-glycero-3-PC (DOPC)은 두 개의 올레산 체인(18:1)을 포함하는 불포화된 인산질이 있으며, 일반적으로 미첼, 리포솜 및 기타 유형의 인공 막 형성을 위해 사용된다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4235-95-4
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleoyl-sn-glycero-3-PC (DOPC)은 두 개의 올레산 체인(18:1)을 포함하는 불포화된 인산질이 있으며, 일반적으로 미첼, 리포솜 및 기타 유형의 인공 막 형성을 위해 사용된다.1,2-Dioleoyl-sn-glycero-3-PC는 듀데실-β-D-말토피라노사이드(DDM)에서 정제된 단백질을 혼합 PC-DDM 미첼로 만들기 위해 포함할 수 있다[2].안정적인 인지질 이중구조 (phospholipid bilayers)를 형성할 수 있으며,이는 다양한 생리 조건에서 다중 구성 요소 생물막의 구조 변화를 연구하는 데 사용된다[3]. 1,2-Dioleoyl-sn-glycero-3-PC는 또한 약물, 단백질 및 핵산의 포장에 사용된다[4]. 중성 지질로서 1,2-Dioleoyl-sn-glycero-3-PC는 세포 신호 전달에 최소한의 영향을 미치며, 인산 질(PA)가 Hippo 신호 경로에 미치는 특정 효과를 구별하기 위한 대조로 사용할 수 있다[5].
References:
[1] Efrat M, Rosenblat M, Mahmood S, et al. Di-oleoyl phosphatidylcholine (PC-18: 1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies[J]. Atherosclerosis, 2009, 202(2): 461-469.
[2] Caldo K M P, Shen W, Xu Y, et al. Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1‐catalyzed phosphorylation[J]. The Plant Journal, 2018, 96(2): 287-299.
[3] Leonenko Z V, Finot E, Ma H, et al. Investigation of temperature-induced phase transitions in DOPC and DPPC phospholipid bilayers using temperature-controlled scanning force microscopy[J]. Biophysical journal, 2004, 86(6): 3783-3793.
[4] Kandregula B, Narisepalli S, Chitkara D, et al. Exploration of lipid-based nanocarriers as drug delivery systems in diabetic foot ulcer[J]. Molecular Pharmaceutics, 2022, 19(7): 1977-1998.
[5] Tei R, Baskin J M. Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds[J]. Journal of Cell Biology, 2020, 219(3): e201907013.
| Cas No. | 4235-95-4 | SDF | |
| Synonyms | sn3Dioleoyllecithin, 1,2Dioleoylsnglycero3Phosphocholine, 1,2DOPC, PDD 111 | ||
| Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O | ||
| Formula | C44H84NO8P | M.Wt | 786.1 |
| Solubility | ≤25mg/ml in ethanol | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.2721 mL | 6.3605 mL | 12.721 mL |
| 5 mM | 0.2544 mL | 1.2721 mL | 2.5442 mL |
| 10 mM | 0.1272 mL | 0.6361 mL | 1.2721 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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