1-Linoleoyl Lysophosphatidic Acid (sodium salt) |
| Catalog No.GC90774 |
글리세로인산지질
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72777-86-7
Sample solution is provided at 25 µL, 10mM.
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1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA) is an agonist of the LPA2 receptor and a glycerophospholipid containing linoleic acid at the sn-1 position.1 It is the most abundant LPA in mouse and human plasma.2,3 1-Linoleoyl LPA selectively increases intracellular calcium levels in LPA2 receptor-expressing Sf9 cells (EC50 = ~10 nM) over LPA1 and LPA3 receptor-expressing Sf9 cells (EC50s = ~200 and ~80 nM, respectively).1 Serum levels of 1-linoleoyl LPA are increased in mice bearing NCTC clone 2472 tumors.4 Plasma 1-linoleoyl LPA levels are decreased in patients with primary progressive, but not relapsing-remitting, multiple sclerosis and are negatively correlated with neurological deficit severity.5
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