12R-LOX-IN-2 |
| Catalog No.GC71326 |
12R-LOX-IN-2(화합물 7b)는 12R 지방산소효소(12R-LOX)의 억제제다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3026677-37-9
Sample solution is provided at 25 µL, 10mM.
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12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases.
References:
[1]. Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.. .
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