2,3-dinor-11β-Prostaglandin F2α-d9 (Synonyms: BPG-d9, 2,3-dinor-11β-PGF2α-d9, 2,3-dinor-11-epi PGF2α-d9) |
| Catalog No.GC46513 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 851030-08-5
Sample solution is provided at 25 µL, 10mM.
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2,3-dinor-11β-Prostaglandin F2α-d9 (2,3-dinor-11β-PGF2α-d9) is intended for use as an internal standard for the quantification of 2,3-dinor-11β-PGF2α by GC- or LC-MS. 2,3-dinor-11β-PG2α was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.1 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts.2 In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC-MS) of the immunoreactive 11β-PGF2α when measured using 's 11β-PGF2α EIA Kit . The excretion rate for 2,3-dinor-11β-PGF2α is approximately 200-250 ng/24 hours in a normal adult.3
1.Liston, T.E., and Roberts, L.J., IIMetabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteerJ. Biol. Chem.260(24)13172-13180(1985) 2.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 3.O'Sullivan, S., Mueller, M.J., DahlÉn, S.E., et al.Analyses of prostaglandin D2 metabolites in urine: Comparison between enzyme immunoassay and negative ion chemical ionization gas chromatography-mass spectrometryProstaglandins Other Lipid Mediat.57(2-3)149-165(1999)
| Cas No. | 851030-08-5 | SDF | |
| Synonyms | BPG-d9, 2,3-dinor-11β-PGF2α-d9, 2,3-dinor-11-epi PGF2α-d9 | ||
| Canonical SMILES | O[C@@H]1[C@H](C/C=C\CC(O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@@H](O)C1 | ||
| Formula | C18H21D9O5 | M.Wt | 335.5 |
| Solubility | DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.9806 mL | 14.9031 mL | 29.8063 mL |
| 5 mM | 0.5961 mL | 2.9806 mL | 5.9613 mL |
| 10 mM | 0.2981 mL | 1.4903 mL | 2.9806 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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