2,3-dinor-8-iso Prostaglandin F2α (Synonyms: 2,3-dinor-iPF2α-III, 2,3-dinor-8-iso PGF2α) |
| Catalog No.GC40416 |
8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 221664-05-7
Sample solution is provided at 25 µL, 10mM.
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8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation. 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats. In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α. Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α. 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml. Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.
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