2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt) |
| Catalog No.GC90803 |
ddA와 ddI의 활성 대사 생성물이며 역전사 억제제입니다.
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Cas No.: 99827-72-2
Sample solution is provided at 25 µL, 10mM.
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2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (Kis = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2′,3′-dideoxyadenosine and didanosine .1,2,3 It is formed from ddI via a 2',3'-dideoxyAMP intermediate by phosphoribosyl pyrophosphate synthase (PRS).3 It inhibits DNA polymerase isolated from mouse Ehrlich ascites tumor cells in the presence of ATP or GDP (Kis = 60 and 18 µM, respectively).4 2',3'-Dideoxyadenosine-5'-O-triphosphate and other dideoxynucleoside 5'-triphosphates are commonly used to terminate chain extension by Taq polymerases in PCR assays.5
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