2'(3')-O-(N'-Methylanthraniloyl)guanosine-5'-O-diphosphate (sodium salt) |
Catalog No.GC90861 |
형광 GDP 유도체
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
2'-O-(N'-Metlanthraniloyl)guanosine-5'-O-diphosphate (2’-MANT-GDP) and 3’-MANT-GDP are fluorescent GDP derivatives, which undergo spontaneous isomerization.1 2’(3’)-MANT-GDP selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, AC6, and bovine lung soluble guanylyl cyclase (sGC; Kis = 430, 2,600, 510, 320, and 4,200 nM, respectively) over B. anthracis edema factor AC toxin, rat testis soluble AC (sAC), and B. pertussis AC toxin (Kis = 37, 48, and 60 µM, respectively). 2’(3’)-MANT-GDP has been used to quantify guanine nucleotide exchange of GTPases.2
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