3-Mercaptopicolinic Acid (hydrochloride) (Synonyms: SKF 34288) |
| Catalog No.GC42300 |
3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 320386-54-7
Sample solution is provided at 25 µL, 10mM.
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3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition.[1][2][3]
Reference:
[1]. DiTullio, N.W., Berkoff, C.E., Blank, B., et al. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem. J. 138(3), 387-394 (1974).
[2]. Robinson, B.H., and Oei, J. 3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase. FEBS Lett. 58(1), 12-15 (1975).
[3]. Hidalgo, J., Latorre, P., Carrodeguas, J.A., et al. Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-mercaptopicolinic acid and novel inhibitors. PLoS One 11(7), e0159002 (2016).
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