(3S,4S)-PF-06459988 |
| Catalog No.GC62165 |
(3S, 4S)-PF-06459988은 덜 활성인 PF-06459988의 S 거울상 이성질체입니다. PF-06459988은 T790M 돌연변이 표피 성장 인자 수용체(EGFR)의 강력한 비가역적 억제제입니다. PF-06459988은 EGFR 야생형에 대해 탁월한 선택성을 가지고 있으며 오프 타겟 라벨링 성향을 감소시키는 최소 반응성 친전자체를 보유하고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1858291-14-1
Sample solution is provided at 25 µL, 10mM.
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(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling[1].
[1]. Cheng, H., et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. Journal of Medicinal Chemistry, 59(5), 2005-2024.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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