>>Lipids>> Reactive O2/N2 Pathways>>8,12-iso-iPF2α-VI-d11

8,12-iso-iPF2α-VI-d11 (Synonyms: 8,12-iso-Isoprostane-F2α-VI-d11, 12-iso-5,6E,14Z-PGF2α-d11, 12-iso-5,6E,14Z-Prostaglandin F2α-d11)

Catalog No.GC46743

A neuropeptide with diverse biological activities

Products are for research use only. Not for human use. We do not sell to patients.

8,12-iso-iPF2α-VI-d11 Chemical Structure

Cas No.: 1616977-85-5

Size 가격 재고 수량
10 μg
US$268.00
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25 μg
US$636.00
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50 μg
US$1,202.00
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Sample solution is provided at 25 µL, 10mM.

Description of 8,12-iso-iPF2α-VI-d11

8,12-iso-isoprostane F-VI-d11 (8,12-iso-iPF-VI-d11) contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8,12-iso-iPF-VI by GC- or LC-mass spectrometry. The relative abundance of deuterium atoms incorporated into each molecule has not been determined. certifies that less that 1% of the product has no deuterium incorporation (<1% d0). Isoprostanes are non-enzymatic, non-cyclooxygenase prostanoid products of peroxidative damage to membrane lipids.1 Among the many isoprostane isomers, 8,12-iso-iPF-VI has been demonstrated to be one of the predominant isomers formed and is also present in urine as one of the major isoprostane products.2 8,12-iso-iPF-VI-d11 is a deuterated internal standard for use in isoprostane quantitation by mass spec modalities. The compound is diastereomeric at C-5, but is otherwise an optically active, single enantiomer.

1.Diaz, M.N., Frei, B., Vita, J.A., et al.Antoixidants and atherosclerotic heart diseaseNew England Journal of Medicine337408-416(1997) 2.Lawson, J.A., Li, H., Rokach, J., et al.Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8,12-iso-isoprostane F2α-VI, in human urineThe Journal of Biological Chemisty27329295-29301(1998)

Chemical Properties of 8,12-iso-iPF2α-VI-d11

Cas No. 1616977-85-5 SDF
Synonyms 8,12-iso-Isoprostane-F2α-VI-d11, 12-iso-5,6E,14Z-PGF2α-d11, 12-iso-5,6E,14Z-Prostaglandin F2α-d11
Canonical SMILES OC(CCCC(O)=O)/C=C/[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@H](O)C[C@@H]1O
Formula C20H23D11O5 M.Wt 365.6
Solubility DMF: >100mg/ml (PGF2 alpha),DMSO: >100mg/ml (PGF2 alpha),Ethanol: >100mg/ml (PGF2 alpha),PBS pH 7.2: 3 mg/ml (PGF2 alpha) Storage Store at -80°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 8,12-iso-iPF2α-VI-d11

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1 mg 5 mg 10 mg
1 mM 2.7352 mL 13.6761 mL 27.3523 mL
5 mM 0.547 mL 2.7352 mL 5.4705 mL
10 mM 0.2735 mL 1.3676 mL 2.7352 mL
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