>>Signaling Pathways>> Ox Stress Reagents>> Lipid Peroxidation>>8-iso Prostaglandin E2 isopropyl ester

8-iso Prostaglandin E2 isopropyl ester (Synonyms: 8iso PGE2 isopropyl ester)

Catalog No.GC42629

8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2.

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8-iso Prostaglandin E2 isopropyl ester Chemical Structure

Cas No.: 330589-21-4

Size 가격 재고 수량
100μg
US$69.00
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1mg
US$165.00
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5mg
US$652.00
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Sample solution is provided at 25 µL, 10mM.

Description of 8-iso Prostaglandin E2 isopropyl ester

8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids.

Chemical Properties of 8-iso Prostaglandin E2 isopropyl ester

Cas No. 330589-21-4 SDF
Synonyms 8iso PGE2 isopropyl ester
Canonical SMILES O=C1[C@@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
Formula C23H38O5 M.Wt 394.6
Solubility DMF: >30 mg/ml (from PGF2a isopropy,DMSO: >50 mg/ml (from PGF2a isopropy,Ethanol: >50 mg/ml (from PGF2a isopropy,PBS pH 7.2: <50 µ g/ml (from PGF2a isopropy Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 8-iso Prostaglandin E2 isopropyl ester

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5342 mL 12.6711 mL 25.3421 mL
5 mM 0.5068 mL 2.5342 mL 5.0684 mL
10 mM 0.2534 mL 1.2671 mL 2.5342 mL
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In vivo Formulation Calculator (Clear solution) of 8-iso Prostaglandin E2 isopropyl ester

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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