α7 nAchR-JAK2-STAT3 agonist 1 |
| Catalog No.GC70953 |
α7 nAchR-JAK2-STAT3 agonist 1은 강력 한 α 7 nAchR-JAK2-STAT3 효능, μ M 32의 IC50 값을 가지고 있는 질소 산화물 ()이 없다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2108714-20-9
Sample solution is provided at 25 µL, 10mM.
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α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis.
References:
[1]. Lin Y, et al. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorg Med Chem. 2022;66:116811.
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