α-Angelica lactone |
| Catalog No.GC61980 |
α-안젤리카 락톤은 자연적으로 발생하는 항암제이자 비닐계 친핵체입니다. α- 안젤리카 락톤은 키랄을 제공할 수 있음 δ-아미노 γ,γ α-안젤리카 락톤은 글루타티온-S-탄스페라제(GST) 및 UDP-글루코노노실트랜스퍼라제(UGT) 해독 효소를 선택적으로 강화하여 강력한 화학 보호 효과를 발휘합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 591-12-8
Sample solution is provided at 25 µL, 10mM.
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α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes[1][2][3][4].
[1]. W A Nijhoff, et al. Quantification of Induction of Rat Oesophageal, Gastric and Pancreatic Glutathione and Glutathione S-transferases by Dietary Anticarcinogens. Carcinogenesis. 1994 Sep;15(9):1769-72.
[2]. E M J van der Logt, et al. Induction of Rat Hepatic and Intestinal UDP-glucuronosyltransferases by Naturally Occurring Dietary Anticarcinogens. Carcinogenesis. 2003 Oct;24(10):1651-6.
[3]. Lin Zhou, et al. Catalytic Asymmetric Vinylogous Mannich-type (AVM) Reaction of Nonactivated α-Angelica Lactone. Org Lett. 2011 Jun 17;13(12):3056-9.
[4]. Jessica A Griswold, et al. Diastereoselective Organocatalytic Addition of α-Angelica Lactone to β-Halo-α-ketoesters. J Org Chem. 2017 Feb 17;82(4):2276-2280.
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