β-Asarone (Synonyms: cis-Asarone) |
| Catalog No.GC40574 |
β-Asarone은 Acorus tatarinowii Schott 뿌리의 주요 성분 중 하나로 중추신경계(CNS)에 상당한 약리작용을 한다.
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Cas No.: 5273-86-9
Sample solution is provided at 25 µL, 10mM.
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β-Asarone은 Acorus tatarinowii Schott 뿌리의 주요 성분 중 하나로 중추신경계(CNS)에 상당한 약리작용을 한다. β-Asarone은 혈액-뇌 장벽(BBB)을 통과할 수 있다[4]. β-Asarone은 단아산산화효소A(MAO-A, IC50 = 142 ± 18 µM)와 단아산산화효소B(MAO-B, IC50 = 362 ± 43 µM)를 억제한다.
β-Asarone (30 µg/mL)은 단백질 킨아스 A(PKA) 경로를 활성화하여 cAMP 반응 요소 결합 단백(CREB)의 인산화를 촉진함으로써 신경 성장 인자 (NGF)가 PC12 세포의 신경 세포 분화를 유도하는 것을 강화한다[6]. β-Asarone은 LPS가 활성화한 BV-2 미세 글리아 세포와 우울증에서 신경 보호 활동을 보인다[2,7-8].
β-Asarone (20, 30 mg/kg/d)은 쥐의 뇌 혈액 공급 중단 및 재공급 후 신경학적 결과를 개선했으며, 특히 신경 행동 기능 측면에서 그렇다[9]. β-Asarone은 베타 아밀로이드 해마 주사 쥐에서의 뉴런 세포사를 억제함으로써 인지 기능을 개선한다[10].
References:
[1]. Cho J, Kim YH, Kong JY, Yang CH, Park CG. Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus. Life Sciences. 2002 Jun 21;71(5):591-9.
[2]. Chen YZ, Wang QW, Liang Y, Fang YQ. Protective effects of beta-asarone on cultured rat cortical neurons damage induced by glutamate. Zhong yao cai= Zhongyaocai= Journal of Chinese Medicinal Materials. 2007 Apr 1;30(4):436-9.
[3]. Fang YQ, Fang RM, Fang GL, Jiang Y, Fu SY. Effects of beta-asarone on expression of c-fos in kindling epilepsy rat brain. Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi= China Journal of Chinese Materia Medica. 2008 Mar 1;33(5):534-6.
[4]. Fang YQ, Wei G. To analyze if the Rhizoma Acori Tatarimowii naph-tha can go through the BBB or not with GC-MS. Zhong Yao Xin Yao Yu: Ling Chuang Yao Li. 2002;3:181-2.
[5]. Tao G, Irie Y, Li DJ, Keung WM. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity. Bioorganic & medicinal chemistry. 2005 Aug 1;13(15):4777-88.
[6]. Lam KY, Chen J, Lam CT, Wu Q, Yao P, Dong TT, Lin H, Tsim KW. Asarone from Acori Tatarinowii Rhizoma potentiates the nerve growth factor-induced neuronal differentiation in cultured PC12 cells: a signaling mediated by protein kinase A. PLoS One. 2016 Sep 29;11(9):e0163337.
[7]. Li C, Xing G, Dong M, Zhou L, Li J, Wang G, Zou D, Wang R, Liu J, Niu Y. Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins. European Journal of Pharmacology. 2010 Jun 10;635(1-3):96-102.
[8].Lim HW, Kumar H, Kim BW, More SV, Kim IW, Park JI, Park SY, Kim SK, Choi DK. β-Asarone (cis-2, 4, 5-trimethoxy-1-allyl phenyl), attenuates pro-inflammatory mediators by inhibiting NF-κB signaling and the JNK pathway in LPS activated BV-2 microglia cells. Food and chemical toxicology. 2014 Oct 1;72:265-72.
[9]. Yang YX, Chen YT, Zhou XJ, Hong CL, Li CY, Guo JY. Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats. BMC Complementary and Alternative Medicine. 2013 Dec;13:1-6.
[10]. Geng Y, Li C, Liu J, Xing G, Zhou L, Dong M, Li X, Niu Y. Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Biological and Pharmaceutical Bulletin. 2010 May 1;33(5):836-43.
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