α-Hydroxyglutaric Acid (Synonyms: 2-HG, 2-Hydroxyglutaric Acid) |
| Catalog No.GC18623 |
α-하이드록시글루타르산(2-하이드록시글루타레이트)은 α-하이드록시산 형태의 글루타르산입니다. α-하이드록시글루타르산은 여러 α-케토글루타레이트 의존성 디옥시게나제(히스톤 데메틸라제 및 5-메틸시토신(5mC) 하이드록실라제의 TET 계열 포함)의 경쟁적 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2889-31-8
Sample solution is provided at 25 µL, 10mM.
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α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.
Review for α-Hydroxyglutaric Acid
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
Review for α-Hydroxyglutaric Acid
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