ACTH (1-39) (trifluoroacetate salt) |
| Catalog No.GC90231 |
MC2R 작용제
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ACTH (1-39) is a potent agonist of melanocortin receptor 2 (MC2R) with an EC50 value of 57 pM in HeLa cells expressing the mouse receptor.1 It induces accumulation of cAMP and release of corticosterone from rat adrenal cells in a concentration-dependent manner.2 ACTH (1-39) also protects neurons from death induced by staurosporine , glutamate, NMDA , AMPA , kainate, quinolinic acid , and reactive oxygen species when used at a concentration of 400 nM.3 Formulations containing ACTH (1-39) have been used in the treatment of systemic lupus erythematosus.
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