Adenylosuccinic Acid (Synonyms: Aspartyl Adenylate) |
| Catalog No.GC46083 |
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Cas No.: 19046-78-7
Sample solution is provided at 25 µL, 10mM.
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Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.[1] It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 µM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.[2] Adenylosuccinic acid (10 µM) increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells.[3] It induces contractions in isolated guinea pig uterus strips when used at a concentration of 100 µM.[4]
Reference:
[1]. Waarde, A. Operation of the purine nucleotide cycle in animal tissues. Biol. Rev. Camb. Philos. Soc. 63(2), 259-298 (1988).
[2]. Halonen, J., and Nedergaard, J. Adenosine 5'-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channel. J. Membr. Biol. 188(1), 183-197 (2002).
[3]. Gooding, J.R., Jensen, M.W., Dai, X., et al. Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism. Cell Rep. 13(1), 157-167 (2015).
[4]. Nishida, Y., and Miyamoto, T. Contractile effect of succinylpurines on guinea pig uterus. Gen. Pharmacol. 19(2), 277-279 (1988).
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