ADH-6 |
| Catalog No.GC64235 |
ADH-6은 트리피리딜아미드 화합물입니다. ADH-6은 돌연변이 p53 DBD의 응집 핵 형성 하위 도메인의 자기 조립을 폐지합니다. ADH-6은 인간 암세포에서 돌연변이 p53 응집체를 표적으로 하고 해리하여 p53의 전사 활성을 회복시켜 세포 주기 정지 및 세포자멸사를 유도합니다. ADH-6은 암 질환 연구의 잠재력을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2227429-65-2
Sample solution is provided at 25 µL, 10mM.
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ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53’s transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].
[1]. Palanikumar L, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12(1):3962.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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