Ald-CH2-PEG5-Boc |
| Catalog No.GC66606 |
Ald-CH2-PEG5-Boc는 PEG- 및 알킬/에테르 기반 PROTAC 링커로 PROTAC 합성에 사용할 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 1446282-23-0
Sample solution is provided at 25 µL, 10mM.
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Ald-CH2-PEG5-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
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