AMI-1 free acid |
| Catalog No.GC39840 |
AMI-1 유리산은 인간 PRMT1 및 효모-Hmt1p에 대해 각각 8.8μM 및 3.0μM의 IC50을 갖는 단백질 아르기닌 N-메틸트랜스퍼라제(PRMT)의 강력한 세포 투과성 및 가역적 억제제입니다. AMI-1 유리산은 펩타이드-기질 결합을 차단하여 PRMT 억제 효과를 발휘합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 134-47-4
Sample solution is provided at 25 µL, 10mM.
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AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding[1].
[1]. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9. [2]. Zhang, B., et al. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget. 2015 Sep 8;6(26):22799-811. [3]. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9. [4]. Baolai Zhang, et al. Arginine Methyltransferase inhibitor-1 Inhibits Sarcoma Viability in vitro and in vivo. Oncol Lett. 2018 Aug;16(2):2161-2166.
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