Amino-PEG11-amine |
Catalog No.GC63930 |
2개의 모노 디에틸스틸베스트롤(DES) 기반 리간드를 결합하는 데 사용되는 PEG 기반(12단위) PROTAC 링커인 아미노-PEG11-아민은 유방암의 내분비 요법을 위한 보다 선택적이고 활성인 ER 길항제를 준비하기 위한 대안 전략을 제공합니다.
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Cas No.: 479200-82-3
Sample solution is provided at 25 µL, 10mM.
Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.
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