Amino-PEG11-amine |
| Catalog No.GC63930 |
2개의 모노 디에틸스틸베스트롤(DES) 기반 리간드를 결합하는 데 사용되는 PEG 기반(12단위) PROTAC 링커인 아미노-PEG11-아민은 유방암의 내분비 요법을 위한 보다 선택적이고 활성인 ER 길항제를 준비하기 위한 대안 전략을 제공합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 479200-82-3
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.
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