Apcin |
| Catalog No.GC18518 |
Cdc20의 리간드인 Apcin은 강력하고 경쟁력 있는 anaphase-promoting complex/cyclosome(APC/C(Cdc20)) E3 ligase 활성 억제제입니다. Apcin은 Cdc20에 결합하고 기질 인식을 방지하여 APC/C 의존적 유비퀴틸화를 경쟁적으로 억제합니다. Apcin은 WD40-domain 측면의 D-box-binding pocket을 차지하고 유사분열을 연장할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 300815-04-7
Sample solution is provided at 25 µL, 10mM.
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Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C). Apcin competitively binds to Cdc20 and prevents substrate interaction and ubiquitylation required for continuation of mitosis. Apcin enhances the effect of the APC/C inhibitor N-4-tosyl-L-arginine methyl ester and its prodrug, proTAME, leading to an increase in the number of cells in mitosis, a longer mitotic duration, and greater stabilization of cyclin B1, cycB1-NT, securin, and cyclin A2. Apcin, in combination with proTAME, synergistically increases apoptosis in multiple myeloma cells.
References:
[1]. Sackton, K.L., Dimova, N., Zeng, X., et al. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C Nature 514(7524), 646-649 (2014).
[2]. Lub, S., Maes, A., De Veirman, K., et al. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells Oncotarget 7(4), 4062-4076 (2016).
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