AZ506 |
| Catalog No.GC64124 |
AZ506은 IC50이 17nM인 강력한 SMYD2 억제제입니다. AZ506은 세포에서 SMYD2 메틸트랜스퍼라제 활성을 억제하여 SMYD2 매개 메틸화 신호를 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2043321-54-4
Sample solution is provided at 25 µL, 10mM.
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AZ506 is a potent SMYD2 inhibitor with an IC50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal[1].
AZ506 inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with an EC50 of 1.2 μM. AZ506 inhibits SMYD2-mediated methylation (p53-me in U2OS cells) with an IC50 of 2.43 μM[1].
[1]. Cowen SD, et al. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J Med Chem. 2016;59(24):11079-11097.
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