Azido-PEG5-acid |
| Catalog No.GC67454 |
아지도-PEG5-산은 접합체 CPT-APO(CPT: Camptothecin )와 같은 PROTAC의 합성에 사용될 수 있는 PEG 기반 PROTAC 링커입니다. 821d96072c2d58d8970e76f526b0f6b8Azido-PEG5-산은 항체-약물 접합체(ADC)의 합성에 사용되는 절단 불가능한 5단위 PEG ADC 링커입니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1425973-16-5
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin ). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Zolotarskaya OY, et al. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Adv. 2015;5(72):58600-58608. Epub 2015 Jun 29.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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