BMS-466442 |
| Catalog No.GC70490 |
BMS-466442 는 asc-1 (아미노산-실크산-시스테인-1) 의 강력한 선택성 억제제로서 IC50은 11nM이다.
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Cas No.: 1598424-76-0
Sample solution is provided at 25 µL, 10mM.
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BMS-466442 dose-dependently inhibits asc-1 activity in human asc-1 expressing cells and primary cultures with IC50 values of 36.8 ± 11.6 nM and 19.7 ± 6.7 nM, respectively[1].
References:
[1]. Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J Neurochem. 2014 Apr;129(2):275-83.
[2]. Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10(5):2510-2517.
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